Left-handed people play guitar or electric bass in either one of the following four ways depending on the person: (1) play a right-handed guitar or bass right-handed, (2) play a true left-handed guitar or bass, (3) play a right-handed guitar or bass that has been altered to play left-handed, or (4) turn a right-handed guitar or bass upside down, pick with the left hand, but leave the strings as they were – which makes them reversed from the normal order for a left-handed player. (The fingering is the same for methods 2 and 3.) Any style of picking with the left hand (flatpicking or fingerstyle guitar) is considered playing left-handed.
Read more about history and origin of the acoustic guitar at wikipedia
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